Table 1 Demographic characteristics of mother-infant pairs in the Ulm birth cohort studies.

From: Influence of infant fucosyltransferase polymorphisms on the association of maternal secretor status with child outcomes: the Ulm birth cohort studies

 

SPATZ (n = 539)

UBCS (n = 488)

n

% or mean

(95%LCL; 95%UCL)

n

% or mean

(95%LCL; 95%UCL)

Child sex

      

 Male

287

53

(49.0; 57.5)

243

49.8

(45.4; 54.2)

 Female

252

47

(42.5; 51.0)

245

50.2

(45.8; 54.6)

Birth weight (g)

538

3390.8

(3352.0; 3429.7)

488

3405.4

(3364.8; 3446.0)

Exclusive breastfeeding

      

 Yes

425

79

(75.4; 82.3)

478

98

(96.7; 99.2)

 No

114

21

(17.7; 24.6)

10

2

(0.8; 3.3)

FUT2 heterozygousity1

      

 Homozygous wild type

143

27

(22.8; 30.3)

150

31

(26.6; 34.8)

 Heterozygous

246

46

(41.4; 49.8)

218

45

(40.3; 49.1)

 Homozygous mutant

92

17

(13.9; 20.2)

74

15

(12.0; 18.3)

 Mixed status

58

11

(8.1; 13.4)

46

9

(6.8; 12.0)

Secretor status2

      

 Secretor

421

78

(74.6; 81.6)

395

81

(77.5; 84.4)

 Non-secretor

92

17

(13.9; 20.2)

74

15

(12.0; 18.3)

 Both

26

5

(3.0; 6.6)

19

4

(2.2; 5.6)

AD up to 2 years

      

 Yes

106

25

(20.8; 29.0)

110

34

(28.8; 39.1)

 No

320

75

(71.0; 79.2)

214

66

(60.9; 71.2)

OM up to 2 years

      

 Yes

120

28

(23.4; 31.8)

177

49

(43.5; 53.8)

 No

315

72

(68.2; 76.6)

187

51

(46.2; 56.5)

LRTI up to 2 years

      

 Yes

207

45

(40.2; 49.2)

319

77

(73.4; 81.5)

 No

256

55

(50.8; 59.8)

93

23

(18.5; 26.6)

URTI up to 2 years

      

 Yes

372

81

(77.3; 84.5)

168

39

(34.5; 43.8)

 No

88

19

(15.5; 22.7)

261

61

(56.2; 65.5)

Maternal age (years)

538

33.2

(32.8; 33.6)

487

32.1

(31.7; 32.5)

Parity (n births of foetus ≥ 24 weeks)

      

 0 births

280

52

(47.8; 56.3)

235

48

(43.7; 52.6)

 ≥ 1 birth

258

48

(43.7; 52.2)

253

52

(47.4; 56.3)

Gestational age at delivery (weeks)

      

 ≤ 36

30

6

(3.6; 7.5)

18

4

(2.0; 5.4)

 Between 36 and 41

423

79

(75.2; 82.1)

367

76

(71.9; 79.5)

 ≥ 41

85

16

(12.7; 18.9)

100

21

(17.0; 24.2)

Delivery mode3

      

 Vaginal

428

80

(76.1; 83.0)

414

85

(81.7; 88.0)

 Cesarean

110

20

(17.0; 23.9)

74

15

(12.0; 18.3)

Maternal secretor status4

      

 Yes

431

80

(76.6; 83.3)

344

71

(66.4; 74.5)

 No

108

20

(16.7; 23.4)

144

30

(25.5; 33.6)

Maternal ABO blood group

      

 A

224

43

(38.9; 47.4)

198

41

(36.5; 45.2)

 B

74

14

(11.3; 17.3)

58

12

(9.1; 14.8)

 O

199

38

(34.2; 42.5)

211

44

(39.1; 47.9)

 AB

22

4

(2.5; 6.0)

18

4

(2.0; 5.4)

Rhesus factor

      

 Positive

426

82

(79.1; 85.7)

411

85

(81.5; 87.9)

 Negative

91

18

(14.3; 20.9)

74

15

(12.1; 18.5)

Maternal milk group/Lewis blood group (UBCS)5

      

 I/A−B+

399

74

(70.3; 77.7)

341

70

(65.8; 73.9)

 II/A + B−

101

19

(15.4; 22.0)

77

16

(12.5; 19.0)

 III/A−B−

32

6

(3.9; 7.9)

67

14

(10.7; 16.8)

 IV/A + B+

7

1

(0.3; 2.3)

3

1

(0.0; 1.3)

Mother-child secretor matches

      

 Secretor to secretor

359

67

(62.6; 70.6)

293

60

(55.7; 64.4)

 Non-secretor to non-secretor

40

7

(5.2; 9.6)

35

7

(4.9; 9.5)

 Secretor to non-secretor

52

10

(7.2; 12.1)

39

8

(5.6; 10.4)

 Non-secretor to secretor

62

12

(8.8; 14.2)

102

21

(17.3; 24.5)

 Status mix

26

5

(3.0; 6.6)

19

4

(2.2; 5.6)

  1. AD, Atopic dermatitis; OM: Otitis media, LRTI: Lower respiratory tract infections; URTI, Upper respiratory tract infections; SPATZ, Ulm SPATZ Health Study; UBCS, Ulm Birth Cohort Study. Sums (n) may not always add up to the total because of missing values for certain items.
  2. 1Infant fucosyltransferase-2 (FUT2) secretor status was determined from the three single-nucleotide polymorphisms (SNPs), rs281379, rs516246 and rs602662.
  3. 2Secretors: SeSe and/or Sese for all SNPs; non-secretors: sese for all SNPs; Mixed: combination of homozygous mutant and other genotypes.
  4. 3Delivery mode: spontaneous or assisted vaginal delivery; or elective/emergency caesarean section.
  5. 4Maternal secretor status based on human milk oligosaccharides (HMOs) in SPATZ or Lewis blood group antigens in UBCS. Secretors: A-B + or A + B+, non-secretors: A + B− or A−B−.
  6. 5Maternal milk group was defined by HMO quantification in SPATZ, or on Lewis AB status in UBCS, shown in parentheses.