Table 1 Characteristics of patients and tumors.

From: Prognostic impact of tertiary lymphoid structures and cancer-associated fibroblasts in hepatocellular carcinoma with portal vein tumor thrombus

Variables

iTLS + (n = 28)

iTLS - (n = 55)

p value

pTLS + (n = 42)

pTLS - (n = 41)

p value

Age (year)

54.54 ± 9.26

53.29 ± 11.84

0.629

53.36 ± 8.66

54.07 ± 13.07

0.769

Gender

  

0.428

  

0.261

Male

22

47

 

33

36

 

Female

6

8

 

9

5

 

Child Pugh score

  

0.879

  

0.743

5

22

44

 

34

32

 

6

6

11

 

8

9

 

Alb (g/L)

40.46 ± 4.57

39.98 ± 5.45

0.689

39.40 ± 4.88

40.90 ± 5.35

0.187

PT (s)

13.41 ± 0.96

13.64 ± 0.68

0.216

13.63 ± 0.82

13.49 ± 0.76

0.436

APTT (s)

37.71 ± 5.49

37.83 ± 4.93

0.921

38.19 ± 5.29

37.39 ± 4.92

0.48

ALT (U/L)

48.14 ± 28.25

44.62 ± 27.89

0.592

46.76 ± 27.38

44.83 ± 28.71

0.754

AST (U/L)

54.93 ± 41.38

48.47 ± 33.91

0.449

48.76 ± 36.30

52.59 ± 37.00

0.636

TB (µmol/L)

13.79 ± 7.33

15.80 ± 12.92

0.45

14.13 ± 14.17

16.13 ± 7.46

0.424

Cause of hepatitis

      

HBV

25

43

0.214

33

35

0.421

HCV

0

1

0.361

1

0

1

Cirrhosis

  

0.21

  

0.189

Positive

16

39

 

25

30

 

Negative

12

16

 

17

11

 

AFP (ng/ml)

  

0.003

  

0.591

≤ 400

11

40

 

27

24

 

>400

17

15

 

15

17

 

Tumor size (cm)

7.15 ± 3.66

7.80 ± 3.75

0.449

7.00 ± 3.78

8.18 ± 3.58

0.147

Tumor number

  

0.659

  

0.212

Solitary

18

38

 

31

25

 

Multiple

10

17

 

11

16

 

MVI

  

0.073

  

0.567

Positive

20

28

 

23

25

 

Negative

8

27

 

19

16

 

Tumor differentiation

  

0.922

  

0.931

Poor

17

34

 

26

25

 

moderate or well

11

21

 

16

16

 

Type of portal vein tumor thrombus

  

0.421

  

0.519

vp1

2

3

 

4

1

 

vp2

8

24

 

15

17

 

vp3

15

26

 

20

21

 

vp4

2

2

 

3

2

 

Fibrotic thickness around the tumor (mm)

0.24 ± 0.15

0.16 ± 0.15

0.014

0.14 ± 0.14

0.23 ± 0.15

0.005

Fibrotic thickness in the tumor (mm)

0.09 ± 0.10

0.06 ± 0.10

0.329

0.04 ± 0.06

0.10 ± 0.13

0.003

Treatment after recurrence

14

24

0.7511

22

23

0.9049

Hepatectomy

4

8

 

8

4

 

RFA

1

3

 

2

2

 

TACE

5

15

 

9

11

 

HAIC

2

1

 

1

2

 

Radiotherapy

2

2

 

1

3

 

Best supportive care

 

1

  

1

 

Pulmonary lobectomy

 

1

 

1

  
  1. Abbreviations iTLS, Intratumoral Tertiary Lymphoid Structures; pTLS, Peritumoral Tertiary Lymphoid Structures; Alb, Albumin; PT, Prothrombin Time; APTT, Activated Partial Thromboplastin Time; ALT, Alanine Aminotransferase; AST, Aspartate Aminotransferase; TB, Total Bilirubin; HBV, Hepatitis B Virus; HCV, Hepatitis C Virus; AFP, Alpha-Fetoprotein; MVI, Microvascular Invasion; RFA, Radiofrequency Ablation; TACE, Transarterial Chemoembolization; HAIC, Hepatic Arterial Infusion Chemotherapy.
Back to article page