Table 3 Multivariate analysis of factors associated with early major neurological improvement in patient with successful recanalization (validation cohort, n = 164).

From: NIHSS mismatch as a predictor of early neurological improvement after mechanical thrombectomy

Variable

Un-adjusted

Model 1*

Model 2**

OR (95% CI)

P

Adjusted

OR (95% CI)

P

Adjusted

OR (95% CI)

P

Demographic data and comorbidities

Age, years

0.975 (0.951–0.999)

0.043

-

-

-

-

Male sex

0.677 (0.357–1.285)

0.233

    

Diabetes mellitus

0.604 (0.297–1.226)

0.163

-

-

-

-

Coronary heart disease

0.287 (0.104–0.797)

0.017

-

-

-

-

Previous stroke

1.961 (0.840–4.581)

0.120

-

-

-

-

Stroke severity

  

-

-

-

-

NIHSS on admission

1.075 (1.012–1.142)

0.020

1.092 (1.018–1.172)

0.014

1.085 (1.012–1.163)

0.021

NIHSSmismatch%

1.056 (1.030–1.082)

< 0.001

1.062 (1.033–1.092)

< 0.001

 

NIHSSmismatch%>75

5.455 (2.596–11.462)

< 0.001

 

5.687 (2.562–12.623)

0.007

NCCT-ASPECT on admission

1.445 (1.128–1.850)

0.004

-

-

-

-

Mechanical thrombectomy data

  

-

-

-

-

Onset-to-door time, min

0.998 (0.997–0.999)

0.058

-

-

0.998 (0.996–0.999)

0.048

Door-to-groin puncture time, min

0.996 (0.991–1.001)

0.085

0.995 (0.990–0.999)

0.038

0.994 (0.9889–0.999)

0.022

Number of passes

0.830 (0.701–0.983)

0.028

0.773 (0.637–0.938)

0.009

0.759 (0.623–0.926)

0.007

Glycaemia on admission mg/dL

0.994 (0.987–1.001)

0.076

-

-

-

-

  1. *Model 1: Forward Stepwise Logistic regression analysis adjusted for the variables listed except for NIHSSmismatch% >75. Cox and Snell R2 = 0.212.
  2. **Model 2: Forward Stepwise Logistic regression analysis adjusted for the variables listed except for NIHSSmismatch%. Cox and Snell R2 = 0.231.
  3. NIHSS, National Institutes of Health Stroke Scale; NCCT, non-contrast computed tomography.