Fig. 3 | Scientific Reports

Fig. 3

From: Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editing

Fig. 3

Generation of porcine OCA1 models. (A) Depiction of WT and porcine OCA1 pig models through photographs. (B) T7E1 assay for Cas9-mediated cleavage at TYR-targeting sites in porcine OCA1 models. (C) Assessment of mutation patterns at the Cas9 target sites of porcine OCA1 models. (D) Examination of off-target editing frequency induced by Cas9-mediated gene editing in porcine OCA1 models. (E,F) Graphical representation illustrating the body weight (E) and survival rates (F) of porcine OCA1 models (n = 4).

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