Fig. 4 | Scientific Reports

Fig. 4

From: Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editing

Fig. 4

Phenotypic analysis of porcine OCA1 models. (A) Visual representation of observed differences in eyes and hair between WT and porcine OCA1 models. (B) Histological examination of eyes and skin by H&E staining. Ch, Choroid; Sc, Sclera; HF, Hair follicle; EP, Epidermis; DM, Dermis. (C) Evaluation of TYR protein expression in skin tissues from both WT and porcine OCA1 models. (D) Relative mRNA expression levels of genes associated with pigmentation in skin tissues from both WT and porcine OCA1 models. (E) Pedigree of crosses between the founder (F0) OCA1 pig and four WT pigs, and representative photographs of F0 (OCA1 pig-1) and F1 (offspring F1-1) OCA1 pigs.

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