Fig. 5
Methylation analysis of Netrin1 and its receptors. (a) The difference of Netrin1 and its receptor genes in methylation bubble map between TCGA cancer and normal samples. The blue dot represents the downregulation of methylation in the tumor, and the red dot represents the upregulation of methylation in the tumor. The darker the color, the greater the difference. The size of the dot represents the statistical significance. The larger the dot, the more significant it is. (b) The relationship between methylation and the expression of Netrin1 and its receptor genes in TCGA cancer. The blue dot indicates that the level of gene methylation was upregulated and the gene expression was downregulated. The red dot indicates that the level of gene methylation was upregulated and the gene expression was also upregulated. The darker the color, the higher the correlation. The size of the point represents the statistical significance; the larger the size, the more significant it is. (c) UNC5D methylation and survival graph. (d) UNC5D methylation and the pathological stage diagram. (e) UNC5D methylation and pathologic T-stage diagram. (f) UNC5D methylation cytosine-phosphate-guanine(CpG) distribution map. (g) 7-CpG methylation box diagrams of the Island.
