Fig. 3

Seed-based nigral networks in PwPD and healthy controls on subject- and group-level. (a) SPM result of first-level single-subject regression analysis using the left substantia nigra as seed visualised on MNI standard template. Sagittal, coronal and axial view of regions of subject-level contrast images. Color bar represents subject-level effect in contrast images. Displayed slices are positioned at axial z = −14, + 8, coronal y= −14 and sagittal x= −9. (b) Group-level t-maps obtained by voxel-wise analysis of [¹⁸F]-FDG PET contrast images from 13 healthy controls or 14 PD patients (P < 0.05 after FWE cluster level correction). Color bar represents t-values of a voxel wise one-sample t-test of contrast images.