Fig. 1
From: The accumulation of extracellular K+ as in vivo model of epilepsy in CA1 pyramidal neurons
(a) Morphology of the CA1 pyramidal neuron used for all simulations and typical synaptic inputs. Green, blue, and pink circles represent recording locations (soma and two dendrites, respectively). The red circles represent the position of all other synapses. (b) Raster plot representing synaptic activation times recorded in vivo from CA3 pyramidal neurons for 10 min (600 s). (c) Somatic membrane potential under the control condition in response to the synaptic activations as in (b). (d) Enlargements of the somatic and typical dendritic membrane potential around 300 and 600 s under control condition. Colored markers represent recording locations. Note that dendritic spikes did not systematically propagate to the soma. Traces were truncated to improve readability. Dendritic action potentials have a typical peak membrane potential around 0 mV (i.e. an amplitude of ~ 50–60 mV), as in the experiments (e.g.33) Full traces are shown in Supplementary Figure SF2.
