Fig. 4

Typical somatic and dendritic recordings from simulations under different conditions. Colored areas in the middle panels represent region with τ₂ = 900 ms and τ_3,4 = 1150 ms (pink), synaptic input locations (yellow), and area with shifted I_A (green). a) Somatic (top) and apical dendrite (bottom) membrane potential with synaptic inputs in the Stratum Radiatum (yellow area) with high synaptic weights (60 nS) and using τ₂ = 900 ms and τ_3,4 = 1150 ms as [K⁺]_e decay time constant (see white marker in Fig. 3, right) for the entire neuron (pink area). b) Soma (top) and basal dendrite (bottom) membrane potential with synaptic input in the Stratum Lacunosum Moleculare (yellow area); peak synaptic weight was reduced by ~ 30% (43 nS) to consider the lower number of synaptic inputs in this area compared to the apical dendrites³⁴; [K⁺]_e decay time constants as in (b) for entire neuron (pink area). (c) Soma (top) and apical dendrite (bottom) membrane potential with synaptic inputs in the Stratum Radiatum (yellow area, right) with high synaptic weights (60 nS), but restricting the area with slow [K⁺]_e decay to the Stratum Radiatum (pink area, right). (d) Soma (top) and apical dendrite (bottom) membrane potential after a -7 mV shift of the A-type K⁺ current activation curve (green area) over the somatodendritic region; simulation conditions as in Fig. 4a (pink area). e) Number of somatic spikes elicited as function of time during simulations under the different conditions considered in this work (the caption for each plot indicates the relative figure and simulation panel, with “SF1” corresponding to the traces shown in Figure SF1).