Fig. 7
From: Impact of mild hyperthermia on tumor-immune dynamics explored through mathematical modeling
Effect of moderate hyperthermia on the tumor proliferation rate \(\alpha\) for three different cancer cell lines, estimated by fitting a logistic growth model \(dT/dt=\alpha (1-\beta T)\) to experimental data at varying temperatures. Panel (a) corresponds to breast adenocarcinoma using data from 56, (b) to B16 murine melanoma based on 36, and (c) to C6 rat glioma according to 37. In all three cases, a clear negative linear relationship is observed between temperature and \(\alpha\), indicating that increasing temperature within the moderate hyperthermia range (\(39-42^\circ\)C) reduces the intrinsic tumor growth rate.
