Fig. 3

Normalized expression of proteasome core subunits 72 h after treatment with ledprona (dsPSMB5), nonspecific control dsRNA (dsGFP) or water. A Wald test for significance was implemented in DeSeq2. Asterisks represent adjusted p-values (*0.05–10− 5, **10− 5–10− 20, ***< 10− 20). Green and black asterisks show genes upregulated and downregulated, respectively, in the ledprona group compared to controls.