Table 1 Statistical and expression data for the top five most significantly upregulated and downregulated genes in ledprona-treated RNA-Seq libraries compared to non-target controls.
Gene | Full gene annotation | Transcript accession | Adjusted p-value | Fold Change | |
|---|---|---|---|---|---|
Upregulated | DNAJA1 | dnaJ homolog subfamily A member 1 (LOC111517751) | XM_023174013.1 | 7.36E-145 | 3.03 |
CRYAB | α-crystallin B chain-like (LOC111505783) | XM_023160649.1 | 8.09E-140 | 98.26 | |
L(2)EFL | protein lethal(2)essential for life-like (LOC111505782) | XM_023160648.1 | 8.44E-131 | 92.25 | |
ADRM1 | proteasomal ubiquitin receptor ADRM1-like (LOC111509886) | XM_023165742.1 | 9.06E-129 | 2.36 | |
PSMC4 | 26 S proteasome regulatory subunit 6B (LOC111507999) | XM_023163409.1 | 1.69E-128 | 3.04 | |
Downregulated | PSMB5 | proteasome subunit β5 (LOC111503877) | XM_023158308.1 | 4.88E-132 | 0.12 |
PGLP1 | phosphoglycolate phosphatase 1B, chloroplastic-like (LOC111512465) | XM_023168586.1 | 3.17E-62 | 0.44 | |
HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like (LOC111509361) | XM_023165086.1 | 3.88E-30 | 0.15 | |
uncharacterized LOC111509358 (LOC111509358) | XM_023165080.1 | 3.27E-25 | 0.1 | ||
RALDH1 | retinal dehydrogenase 1-like (LOC111506486) | XM_023161556.1 | 3.75E-23 | 0.52 |
