Fig. 7
Prognostic analysis of MYLK2 using Cox regression models. (A) Univariate Cox regression analysis presenting hazard ratios (HR) for various clinical characteristics, including pathologic T and N stages, and MYLK2 expression. Significant results are marked (e.g., MYLK2 high expression: HR = 1.394; 95% CI: 1.010–1.924; P = 0.043). (B) Multivariate Cox regression analysis highlighting the adjusted HR for clinical factors influencing survival outcomes, emphasizing the significance of MYLK2 along with pathologic N stage and age (> 60 years: HR = 2.774; P < 0.001). (C) Nomogram predicting 1-, 3-, and 5-year survival probabilities based on clinical characteristics and MYLK2 expression, providing a linear predictor for survival estimation. (D) ROC curve analysis of MYLK2, showing sensitivity and specificity, with an AUC of 0.892, indicating good predictive performance of the model. (E) Calibration plot comparing the predicted survival probabilities from the nomogram with observed outcomes, demonstrating model accuracy for 1-, 3-, and 5-year predictions.
