Fig. 7
From: Age-related evolution of human gingiva towards a fibrotic-like connective phenotype
Predicting gingival age to obtain a minimal gene signature. From a clinical perspective, intercepting individuals whose biological gingival age exceeds their chronological age could allow for personalized preventive strategies to delay or prevent the progression to overt periodontal pathology. (A) A partial least square regression (sPLS) was performed to explain chronological age based on the normalized counts of the “S” genes, which showed differential expression with age. A total of 10 genes were selected by the model as necessary for dimension 1, and 11 genes for dimension 2 to effectively explain chronological age (S signature). (B) A linear regression model was then built using the genes of S signature to explain chronological age, adjusting for periodontal health categories (healthy, gingivitis, periodontitis) and gender.
