Fig. 7 | Scientific Reports

Fig. 7

From: hsa_circ_0001818 regulates the function of macrophages in sepsis by inhibiting miR-17-3p, miR-433-3p, and miR-642a-5p

Fig. 7

miR-433-3p and miR-642a-5p regulate the inflammatory response of THP-1-derived macrophages by targeting ZBTB20/NF-κB. (a) Expression level of ZBTB20 mRNA after overexpression and silencing of miR-433-3p and miR-642a-5p. (b) Expression level of ZBTB20 protein after overexpression and silencing of miR-433-3p and miR-642a-5p. (c) Expression level of phosphorylated proteins related to the NF-κB pathway after overexpression and silencing of miR-433-3p and miR-642a-5p. (d) Levels of inflammatory cytokines (TNF-α, IL-6, and IL-1β) secreted by THP-1-derived macrophages after overexpression and silencing of miR-433-3p and miR-642a-5p. *P < 0.05, **P < 0.01, and ***P < 0.001.

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