Fig. 14 | Scientific Reports

Fig. 14

From: Chitosan-functionalized mesoporous silica nanoparticles co-loaded with chrysin and quercetin: a potent strategy against lung cancer cells

Fig. 14

Analysis of apoptosis-related gene expression in A549 cells following treatment with Qur and Chr, delivered either in free form or as nanoformulations. (A) The mRNA expression of anti-apoptotic genes (Rbp, Cyclin D1, and Bcl2) was markedly decreased in the treated groups compared with the control. (B) Conversely, the expression of pro-apoptotic genes (Bax, Fas, and P53) was significantly increased after treatment with control, free Chr, free Qur, Chr–NPs, Qur –NPs, Chr–Qur, and Chr-Qur@MSNsChi NPs for 48 h. Error bars represent standard deviations. (*P value < 0.05, **P value < 0.001).

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