Fig. 5 | Scientific Reports

Fig. 5

From: Design, synthesis and biological activity of glycoconjugated ADAMTS5 exosite inhibitors: applications in osteoarthritis and ovarian cancer models

Fig. 5

Effect of compounds 2 and 4b on cell viability. Compounds 2 and 4b or DMSO control were incubated with HEK293T cells (A), human non-OA chondrocytes (B), porcine cartilage explants (C), or human OA cartilage explants (D) for 72 h. Cell viability was measured using MTS assay and reported as percentage of DMSO control. Data are plotted as scatter dot plots with average ± S.E.M. (n = 3–4 independent experiments with 3 technical replicates per experiment). *p < 0.05; **p < 0.005; ****p < 0.0001 compared to DMSO control by one-way ANOVA.

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