Fig. 6 | Scientific Reports

Fig. 6

From: Design, synthesis and biological activity of glycoconjugated ADAMTS5 exosite inhibitors: applications in osteoarthritis and ovarian cancer models

Fig. 6

Anti-aggrecanolytic effect of compounds 2 and 4b on human OA cartilage explants. Compounds 2 and 4b or DMSO were incubated with cartilage explants from OA patients. (A) Representative anti-AGEG immunoblot. ADAMTS5-digested bovine aggrecan was used as a positive control. Asterisk indicates non-specific bands. (B) Densitometric analysis of immunoreactive bands. Data are plotted as scatter dot plots with average ± S.E.M. (n = 3 donors). ***p < 0.001; ****p < 0.0001 compared to DMSO control by one-way ANOVA. ATS5, ADAMTS5; Cpd, compound.

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