Table 1 Number of ChEMBL compounds similar to 4b and 2 according to similarity estimations.
Cell line | Intervals of activity | Number of compounds similar to 4b (TT-fp) | Number of compounds similar to 2 (TT-fp) |
|---|---|---|---|
HEK293 | < 1 µM | 4 | 0 |
≥ 1 to <10 µM | 4 | 0 | |
≥ 10 to <50 µM | 9 | 19 | |
≥ 50 µM | 14 | 38 | |
HeLa | < 1 µM | 30 | 28 |
≥ 1 to <10 µM | 78 | 54 | |
≥ 10 to <50 µM | 157 | 109 | |
≥ 50 µM | 96 | 141 | |
HepG2 | < 1 µM | 32 | 16 |
≥ 1 to <10 µM | 125 | 61 | |
≥ 10 to <50 µM | 193 | 96 | |
≥ 50 µM | 80 | 103 | |
SH-SY5Y | < 1 µM | 47 | 7 |
≥ 1 to <10 µM | 1 | 1 | |
≥ 10 to <50 µM | 6 | 1 | |
≥ 50 µM | 0 | 15 | |
THP-1 | < 1 µM | 5 | 2 |
≥ 1 to <10 µM | 10 | 2 | |
≥ 10 to <50 µM | 3 | 1 | |
≥ 50 µM | 12 | 11 |
