Fig. 3
From: TIR-domain-containing protein C as modulator of innate immune checkpoints
Poor response of HK-2 cells to CFT073 infection. Kidney proximal tube epithelial HK-2 (A,C,E) and human bladder epithelial T24/83 cells (B,D,F) were infected for 5 h with CFT073, CFT073ΔtcpC or CFT073ΔtcpC + pTcpC with different MOIs as indicated. IL-6 (A,B), IL-8 (C,D) and TNFα levels (E,F) were determined in the culture supernatant. LPS + ATP served as positive, medium as negative control. The experiments were repeated thrice with similar results, each bar represents three replicates. *P < 0.01, ***P < 0.001, ****P < 0.0001, two-way ANOVA, post hoc Tukey.
