Fig. 1 | Scientific Reports

Fig. 1

From: Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival

Fig. 1

Morphological tumor necrosis and relation to female breast cancer features and a necrosis-specific gene expression signature score. (A) Left: The Breast Cancer Necrosis Signature (BCNS) score (ordered from low to high) calculated from mRNA expression data. Right: Boxplot of the BCNS score levels assessed by histopathological evaluation (HE) of necrosis status28. (B) A high breast cancer necrosis score (n = 93) is associated with basal like PAM50 subtype, and loss/low levels (negativity) of Estrogen receptor (ER) alpha and Progesterone receptor (PR), and HER2 positivity, compared to the patient group with low score (n = 390). Data from the TCGA BRCA study26, with normal-like molecular subtype excluded from analysis, n = 483.

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