Table 1 The relation between morphologic (HE) necrosis and clinico-pathologic features in the TCGA cohort (BRCA, n = 483).

From: Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival

Variable

Necrosis absent (N-)

Necrosis present (N+)

P-value†

No. patients

n = 331

n = 152

 

ER status (IHC)

 Positive

292 (89.6%)

73 (48.7%)

 < 0.001

 Negative

34 (10.4%)

77 (51.3%)

PR status (IHC)

 Positive

255 (78.7%)

57 (37.7%)

 < 0.001

 Negative

69 (21.3%)

94 (62.3%)

HER2 (IHC)

 Negative

277 (86.3%)

118 (81.9%)

0.262

 Positive

44 (13.7)

26 (18.1)

Molecular subtype (PAM50)

 Luminal A

186 (56.2%)

33 (21.7%)

 < 0.001

 Luminal B

90 (27.2%)

26 (17.1%)

 HER2-enriched

32 (9.7%)

24 (15.8%)

 Basal-like

23 (6.9%)

69 (45.4%)

  1. †Chi-square test, two sided. n = number of patients. Missing cases: ER, n = 7; PR, n = 8; HER2, n = 18.
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