Scientific Reports

Table 4 Cox multivariate survival analysis (METABRIC Discovery cohort).

From: Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival

Variable	n(%)	HR	95% CI	P-value	HR	95.0% CI	P-value
Unadjusted					Adjusted
Tumor size				< 0.001			0.003
≤ 20 mm	409 (44)	1.0			1.0
> 20 mm	530 (56)	2.0	1.5–2.6		1.5	1.2–2.0
Histologic grade				< 0.001			0.06
Grade 1/2	456 (49)	1.0			1.0
Grade 3	483 (51)	1.9	1.4–2.4		1.3	0.98–1.8
Lymph node status				< 0.001			< 0.001
Negative	482 (51)	1.0			1.0
Positive	457 (49)	2.5	1.9–3.2		2.0	1.5–2.7
BCNS score	939 (100)	1.005	1.003- 1.006	< 0.001	1.003	1.001- 1.005	0.006

HR = Hazard ratio, CI = Confidence interval, n = number of patients.
The Breast Cancer Necrosis Signature (BCNS) score included as continuous variable (n = 939).

Back to article page

Search

Advanced search

Quick links