Fig. 3 | Scientific Reports

Fig. 3

From: Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches

Fig. 3

The predicted secondary structure of protein and mRNA of the screened vaccine construct (hMPV-beta1) : (a)-represents the helix, sheet, turns, and coils in the secondary protein structure of the construct (hMPV-beta1), (b)-mRNA secondary structure (MFE-SE-str = mean free energy secondary structure and c-SE-str = centroid secondary structure), (c)-mountain plot representing the mean free energy, thermodynamic ensemble, and centroid structure of mRNA, and entropy plot illustrating positional entropy for each position in mRNA. MFE (blue) = minimum free energy structure, showing the most thermodynamically stable configuration; PF (green) = partition function, representing the statistical ensemble of structures contributing to RNA stability; and Centroid (red): The centroid structure, which is the most representative structure from the ensemble.

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