Fig. 7 | Scientific Reports

Fig. 7

From: Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches

Fig. 7

NMA of TLRs-vaccine and MHCs-vaccine complexes. (a): NMA results of TLR4-hMPVbeta1, (b) NMA results of TLR2-hMPVbeta1, (c) NMA results of MHC class I-hMPVbeta1 and (d) NMA results of MHC class II-hMPVbeta1 complexes. Left-side plot; Beta factor/mobility graph (flexibility/deformity value vs. atomic index); middle plot; comparison between the Normal Mode Analysis (NMA) and PDB-derived flexibility data for a protein or molecular complex. The overlay of NMA (red) and PDB (black) provides insight into the consistency between computational and experimentally derived structural flexibility and right-side plot eigenvalues obtained from Normal Mode Analysis (NMA), plotted against the mode indices.

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