Table 1 The Immunogenic potential of prioritized linear B-cell epitopes and promiscuous CTL Epitopes.

From: Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches

Proteins IDs/Proteins

LBL -epitope designation

LBL-epitope

ABCP(s)

Ag(s)

Toxicity

Allergenicity

YP_009513268.1/hMPV-Fp

LBE-1

LGAIALGVATAAAVTA

0.76

1.02

Non-toxic

Non-allergen

LBE-2

NINISTTNYPCKVSTG

0.84

0.94

Non-toxic

Non-allergen

YP_009513272.1/hMPV-Gp

LBE-3

QPDISATTHKNEEASP

0.93

1.09

Non-toxic

Non-allergen

LBE-4

SRTKTSPAVHTKNNPR

0.89

0.6819

Non-toxic

Non-allergen

MH828686.1/hMPV-Mp

LBE-5

KIAPYAGLVMIMTMNN

0.87

0.9084

Non-toxic

Non-allergen

LBE-6

QVDLVEKDLLPASLTI

0.59

1.113

Non-toxic

Non-allergen

YP_009513271.1/hMPV-Shp

LBE-7

LKLILALLTFLTVTIT

0.53

0.67

Non-toxic

Non-allergen

LBE-8

ESDKKDSSSNTTSVTT

0.67

0.49

Non-toxic

Non-allergen

Proteins IDs/Proteins

CTL -epitope

designation

CTL -epitope/allele pair

IC50-value

Ag(s)

Toxicity

Allergenicity

YP_009513268.1/hMPV-Fp

CTL-1

VSFSQFNRR/HLA-A*31:01

13.62

1.614

Non-toxic

Non-allergen

CTL-2

FVLGAIALGV/HLA-A*02:06

4.99

1.276

Non-toxic

Non-allergen

YP_009513272.1/hMPV-Gp

CTL-3

MLKARVKNR/HLA-A*31:01

11.9

1.67

Non-toxic

Non-allergen

CTL-4

KTSPAVHTK/HLA-A*30:01

6.77

1.44

Non-toxic

Non-allergen

MH828686.1/hMPV-Mp

CTL-5

AAMSVLPKK/HLA-A*11:01

10.7

1.11

Non-toxic

Non-allergen

CTL-6

SVLPKKFEL/HLA-A*02:06

76.35

1.19

Non-toxic

Non-allergen

YP_009513271.1/hMPV-Shp

CTL-7

YTVKWKCYHY/HLA-B*15:01

76

2.04

Non-toxic

Non-allergen

CTL-8

LTVTITINYI/HLA-A*68:02

12.09

1.234

Non-toxic

Non-allergen

  1. hMPV = human metapneumovirus, Fp = fusion protein, Mp = matrix protein, Gp = attachment glycoprotein, Shp = short hydrophobic protein, LBL = linear B-cell, ABCP(s) = ABCPred-score, and Ag(s) = antigenicity score (Vaxijen score).
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