Fig. 4

Receiver operating characteristic (ROC) curves for the top two pupillometric parameters for detecting optic neuropathy (17 patients, 30 controls). The absolute RAPD score (solid line; AUC = 0.903, 95% CI: 0.832–0.975) and the intereye constriction percentage difference (dashed line; AUC = 0.811, 95% CI: 0.709–0.912) both demonstrated high diagnostic accuracy. Solid circles on each curve mark the optimal cutoff point as determined by Youden’s index.