Fig. 3 | Scientific Reports

Fig. 3

From: Disulfiram inhibits Gasdermin D pores formation and improves insulin-dependent glucose uptake and glucose homeostasis in skeletal muscle of obesity-induced insulin-resistant mice

Fig. 3

Disulfiram administration improves physiological parameters in obese insulin-resistant mice. HFD-fed 7-week-old mice were intraperitoneally injected with DSF 50 mg/kg or vehicle three times per week for 3 weeks. a Body mass progression (n = 10). b Weekly variation in food intake (n = 10). c Intraperitoneal glucose tolerance test (IPGTT) and its area under the curve (AUC). (n = 10). d Epididymal adipose tissue mass (n = 9). e Fasting insulinemia (n = 9). f Plasma IL-1β levels in HFD-fed mice (n = 7). Results are presented as mean ± SEM and expressed relative to the HFD group.*p < 0.05, ***p < 0.001, and ****p< 0.0001 vs. HFD. HFD: High-fat diet, HFD DSF: High-fat diet injected with disulfiram, FDB: flexor digitorum brevis.

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