Fig. 1 | Scientific Reports

Fig. 1

From: The PI3K-AKT-mTOR signaling pathway mediates epithelial mesenchymal transition and cytoskeletal architecture changes induce to renal fibrosis after Bisphenol S exposure

Fig. 1

Renal function in rats, Masson trichrome staining of kidney tissues and the expression of kidney injury related indicators after BPS exposure. (A) Minor increase in BUN and SCr in all rats was increased slightly after BPS treatment. ns presents no statistically significant difference compared to controls. (B) Immunohistochemistry showed a dose-dependent increase in Kim-1 and NGAL expression after BPS exposure. Scale bar,50 μm. (C) Immunohistochemistry showed a dose-dependent increase in TNF-α, IL-6, HO-1 and Nrf2 expression after BPS exposure. Scale bar,50 μm. (D) Masson trichrome staining results: the collagen fibers of the kidney tissues were significantly increased after BPS exposure, and they were concentrated around the renal tubular epithelium. Scale bar, 100 μm.

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