Fig. 1

Study outline. Three interventional studies of pig anastomosis healing were performed. In each study two hand sewn anastomoses were created in the small intestines on day 0. The length of the studies was varied to allow observation of tolerability of intervention (A, 5-days study) following the initial inflammatory healing phase with provisional wound closure, (B, 10-days study) during the proliferative phase where the tissue strength is dynamically restored, and (C, 28-days study) following the proliferative phase of healing. The sclerotic agent aethoxyklerol and anakinra was used to induce fibrosis and as positive anti-fibrotic treatment control, respectively. Image is created using BioRender.