Fig. 6
From: AFP promotes cancer multidrug resistance through activating PI3K/Akt/NF-κB signaling pathway
Involved molecular mechanism of AFP promoting MDR in cancer cells. AFP can activate the PI3K/AKT signaling pathway, and the activation of this pathway further promotes the activation of NF-κB. The activated NF-κB, such as p65, can translocate into the nucleus. After p65 translocates into the nucleus, on the one hand, it can stimulate the transcription of drug resistance genes, thereby increasing the efflux of chemotherapeutic drugs; on the other hand, it can promote the expression of anti-apoptotic genes, thus enhancing the survival ability of cancer cells.
