Table 3 MIC of the most active compounds by agar diffusion methods.

From: Synthesis, molecular docking, ADMET studies and biological evaluation of fused pyrazolopyridopyrimidine derivatives as antioxidant and antimicrobial agents

Compounds

Concentration

 

Antibacterial activities (mm)

E. coli

ATCC25915

S. aureus

ATCC25923

E. faecalis

ATCC29212

P. aeruginosa

ATCC10145

S. mutans

ATCC 25,175

7

2.0 mg/mL

(+) 10.8 ± 0.13

(+) 11.5 ± 0.05

(+) 8.5 ± 0.43

(+) 12.5 ± 0.07

(+) 16.5 ± 0.43

1.0 mg/mL

(–)

(+) 4.5 ± 0.00

(–)

(+) 5.20 ± 0.01

(+) 5.0 ± 0.03

0.5 mg/mL

(–)

(–)

(–)

(–)

(–)

9

2.0 mg/mL

(+) 8.0 ± 0.11

(+) 12.10 ± 0.00

(+) 9.1 ± 0.40

(+) 14.0 ± 0.00

(+) 10.01 ± 0.11

1.0 mg/mL

(–)

(+) 6.00 ± 0.05

(–)

(+) 7.10 ± 0.05

(–)

0.5 mg/mL

(–)

(–)

(–)

(–)

(–)

11

2.0 mg/mL

(+) 9.5 ± 0.0

(+) 14.60 ± 0.00

(+) 6.5 ± 0.40

(+) 10.0 ± 0.00

(+) 12.01 ± 0.11

1.0 mg/mL

(–)

(+) 8.0 ± 0.15

(–)

(–)

(–)

0.5 mg/mL

(–)

(–)

(–)

(–)

(–)

12

2.0 mg/mL

(+) 6.5 ± 0.0

(+) 13.20 ± 0.00

(+) 10.3 ± 0.40

(+) 10.0 ± 0.00

(+) 8.00 ± 0.11

1.0 mg/mL

(–)

(+) 5.10 ± 0.00

(–)

(–)

(–)

0.5 mg/mL

(–)

(–)

(–)

(–)

(–)

15

2.0 mg/mL

(+) 7.0 ± 0.05

(+) 10.50 ± 0.00

(+) 11.2 ± 0.30

(+) 12.1 ± 0.00

(+) 11.00 ± 0.11

1.0 mg/mL

 

(+) 3.50 ± 0.00

(+) 4.80 ± 0.00

(+) 6.70 ± 0.00

(+) 4.50 ± 0.00

0.5 mg/mL

(–)

(–)

(–)

(–)

(–)