Fig. 4

Functional enrichment mapping of M2-specific differentially abundant proteins (DAPs) relative to monocyte and macrophage subtypes (GMØ, MMØ, and M1) using String enrichment analysis. The significant biological processes were clustered and visualized in Cytoscape using EnrichmentMap and AutoAnnotate. Nodes represent individual GO terms, sized according to the number of genes within each term, and colored based on based on the normalized enrichment scores (NES). Edges, the lines connecting the nodes, are weighted by the thickness, which reflects the richness of shared genes between the connected nodes, illustrating the interconnectedness of biological pathways involved in M2 macrophage functionality.