Fig. 6 | Scientific Reports

Fig. 6

From: Explainable machine learning identifies immune-inflammatory biomarkers and therapeutic candidates in drug-resistant epilepsy

Fig. 6The alternative text for this image may have been generated using AI.

SHAP-based interpretability of classifier features. (A) Top genes ranked by mean absolute SHAP values, including XIRP1, P2RY13, CCL3-AS1, ACY3, and TNF. (B) SHAP summary plot showing directional influence of features such as TNF, CX3CR1, and IL1B. (C–G) Gene-specific SHAP dependence plots demonstrating predictive effects of IL1B, TNF, P2RY12, ACY3, and CD163 on epileptic classification.

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