Fig. 7 | Scientific Reports

Fig. 7

From: Explainable machine learning identifies immune-inflammatory biomarkers and therapeutic candidates in drug-resistant epilepsy

Fig. 7The alternative text for this image may have been generated using AI.

Biological validation through protein networks, ontologies, and pathways. (A) Proteinā€“protein interaction network of prioritized features highlighting TNF, CX3CR1, CCL4, IL1A. (B) Biological process enrichment showing leukocyte adhesion, cytokine secretion, and chemotaxis. (C) Molecular function enrichment, including cytokine receptor activity and chemokine binding. (D) Reactome pathways enriched for IL-10 signaling, purinergic signaling, and antimicrobial response. (E) Transcription factor network identifying SPI1, RUNX1, NFĪŗB1, and GATA factors as upstream regulators.

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