Table 2 The associations between tract-specific FA and longitudinal SDMT scores decline.

From: Preserved white matter integrity is a promising indicator of cognitive resilience in Parkinson’s disease

Tracts Statistics

OR

Lower_CI

Upper_CI

P-value

FDR-corrected P-value

Genu of corpus callosum

0.23

0.07

0.59

0.0042

0.0341

Body of corpus callosum

0.12

0.02

0.42

0.0034

0.0341

Splenium of corpus callosum

0.22

0.07

0.55

0.0030

0.0341

Fornix

0.34

0.10

0.92

0.0580

0.1096

Right corticospinal tract

0.87

0.34

2.18

0.7608

0.8335

Left corticospinal tract

1.03

0.43

2.46

0.9521

0.9808

Right inferior cerebellar peduncle

0.08

0.01

0.42

0.0139

0.0471

Left inferior cerebellar peduncle

0.25

0.05

0.69

0.0308

0.0782

Right superior cerebellar peduncle

0.43

0.17

0.99

0.0564

0.1096

Left superior cerebellar peduncle

0.36

0.12

0.91

0.0424

0.0902

Right cerebral peduncle

0.18

0.04

0.54

0.0060

0.0341

Left cerebral peduncle

0.26

0.08

0.68

0.0106

0.0449

Right anterior limb of internal capsule

0.29

0.10

0.69

0.0086

0.0419

Left anterior limb of internal capsule

0.27

0.09

0.65

0.0060

0.0341

Right posterior limb of internal capsule

0.50

0.19

1.25

0.1488

0.2200

Left posterior limb of internal capsule

0.99

0.40

2.41

0.9808

0.9808

Right retrolenticular part of internal capsule

0.57

0.19

1.42

0.2588

0.3520

Left retrolenticular part of internal capsule

0.48

0.18

1.14

0.1122

0.1733

Right anterior corona radiata

0.28

0.08

0.76

0.0213

0.0653

Left anterior corona radiata

0.20

0.06

0.56

0.0043

0.0341

Right superior corona radiata

0.89

0.38

1.97

0.7845

0.8335

Left superior corona radiata

1.23

0.53

2.84

0.6183

0.7007

Right posterior corona radiata

0.70

0.30

1.65

0.3982

0.4836

Left posterior corona radiata

0.66

0.28

1.56

0.3425

0.4314

Right posterior thalamic radiation

0.45

0.17

1.06

0.0772

0.1313

Left posterior thalamic radiation

0.33

0.10

0.85

0.0324

0.0782

Right superior longitudinal fasciculus

0.31

0.11

0.73

0.0130

0.0471

Left superior longitudinal fasciculus

0.40

0.17

0.87

0.0230

0.0653

Right inferior fronto-occipital fasciculus

0.60

0.21

1.51

0.3027

0.3959

Left inferior fronto-occipital fasciculus

0.51

0.16

1.36

0.2118

0.3001

Right uncinate fasciculus

0.48

0.19

1.13

0.0966

0.1564

Left uncinate fasciculus

0.74

0.31

1.74

0.4917

0.5765

Right tapetum

0.46

0.18

1.04

0.0670

0.1199

Left tapetum

0.39

0.15

0.91

0.0345

0.0782

  1. Logistic regression models were used to assess the associations between tract-specific FA values and longitudinal decline in SDMT scores at follow-up. Statistical significance was defined as a FDR-adjusted P < 0.05, with significant values presented in bold. Abbreviations: CI, confidence interval; OR, odds ratio; FDR, false discovery rate; SDMT, Symbol Digit Modalities Test.
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