Fig. 2

Structure of CAR-LBD. The structure of CAR-LBD consists of 12 helices and one beta sheet (left). The superimposition of agonist (pale cyan) and inverse agonist (wheat) bound conformations (right). The kink region (black circle), AF-2 helix (green color), and the ligands (sticks) are shown. The interaction between helices were shown in square boxes for both agonist and inverse agonist conformations.