Table 1 Meta-analyses between NLR as a continuous variable and DN risk.

From: The predictive value of neutrophil-to-lymphocyte ratio for the occurrence, progression, and mortality of diabetic nephropathy: a systematic review and meta-analysis

Groups/subgroups

N

SMD [95%CI]

P value

I2(%)

Total

19

1.31 [0.96–1.66]

< 0.00001

95

Region

 South Asia

8

1.43 [0.86–2.01]

< 0.00001

95

 East Asia

5

0.79 [0.33–1.26]

0.0009

94

 West Asia

4

1.25 [0.41–2.10]

0.003

94

Mean/median age

 ≥ 60

4

0.92 [0.59–1.24]

< 0.00001

75

 < 60

15

1.42 [0.96–1.88]

< 0.00001

96

NLR cutoff

 ≥ 2.4

3

0.81 [0.42–1.20]

< 0.0001

80

 < 2.4

6

1.54 [0.80–2.29]

< 0.0001

95

BMI

 ≥ 25

9

1.24 [0.79–1.70]

< 0.00001

94

 < 25

6

1.61 [0.76–2.46]

0.0002

98

FPG

 ≥ 9

5

1.44 [0.41, 2.46]

0.006

97

 < 9

3

1.12 [0.70, 1.55]

< 0.00001

87

Diagnostic markers

 UACR and equivalents

15

1.47 [1.07, 1.88]

< 0.00001

95

 eGFR

4

0.71 [0.14, 1.28]

0.02

93

  1. NLR, neutrophil-to-lymphocyte ratio; DN, diabetic nephropathy; SMD, standardized mean difference; CI, confidence interval; BMI, body mass index; FPG, fasting plasma glucose; eGFR, estimated glomerular filtration rate; UACR, urinary albumin-to-creatinine ratio.
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