Table 2 Meta-analyses between NLR as a categorical variable and DN risk.

From: The predictive value of neutrophil-to-lymphocyte ratio for the occurrence, progression, and mortality of diabetic nephropathy: a systematic review and meta-analysis

Groups/subgroups

N

OR [95%CI]

P value

I2 (%)

Total

14

2.16 [1.85–2.52]

< 0.00001

43

Study design

 Cohort

6

1.85 [1.53–2.25]

< 0.00001

22

 Case-control

8

2.36 [1.96–2.84]

< 0.00001

29

Region

 China

10

2.08 [1.76–2.45]

< 0.00001

49

 Japan

3

2.84 [1.26–6.38]

0.01

29

Mean/median age

 ≥ 60

8

2.29 [1.84–2.86]

< 0.00001

58

 < 60

6

1.94 [1.58–2.37]

< 0.00001

3

NLR cutoff

 ≥ 2.4

3

2.30 [1.50, 3.50]

0.0001

49

 < 2.4

7

2.18 [1.74, 2.72]

< 0.00001

57

BMI

 ≥ 25

4

2.77 [1.64–4.66]

0.0001

57

 < 25

7

2.04 [1.69–2.47]

< 0.00001

48

FPG

 ≥ 9

3

3.58 [1.81, 7.05]

0.0002

31

 < 9

5

2.09 [1.68, 2.60]

< 0.00001

68

Diagnostic markers

 UACR and equivalents

6

2.37 [1.82, 3.08]

< 0.00001

41

 eGFR

8

2.04 [1.67, 2.49]

< 0.00001

47

  1. NLR, neutrophil-to-lymphocyte ratio; DN, diabetic nephropathy; OR, odds ratio; CI, confidence interval; BMI, body mass index; FPG, fasting plasma glucose; eGFR, estimated glomerular filtration rate; UACR, urinary albumin-to-creatinine ratio.
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