Fig. 4

Graph represents the means of interleukins (a) IL-1β; (b) TNF-α and (c) IL-6 levels measured in gingival tissue samples. *p < 0.05; ***p < 0.001. (ANOVA followed by the Bonferroni’s test). Healthy, healthy group; EP, experimental periodontitis; EP + TCZ, experimental periodontitis + Tocilizumab.