Fig 3 | Scientific Reports

Fig 3

From: Targeting fibroblast activation protein in solid tumors via LNP-mediated CAR-mRNA delivery promotes durable regression in murine models

Fig 3The alternative text for this image may have been generated using AI.

mRNA-LNP exerts anti-tumor effects in PDX models. (a) Schematic overview of the experimental design, which was created with BioRender.com. (b) Individual tumor growth curves in PDX-1. (c) Individual tumor growth curves in PDX-2. (d) GSE analysis in PDX-1. Gene ontology (GO) terms enriched in the group treated with 7SL1-like RNA-expressing immune cells and mRNA-LNP compared to the PBS control. (e) GSE analysis in PDX-2. GO terms and Hallmark gene sets enriched in the group treated with 7SL1-like RNA-expressing immune cells and mRNA-LNP compared to the PBS control. (f) GSE analysis in PDX-2. GO terms and Hallmark gene sets enriched in the group treated with wild-type immune cells and mRNA-LNP compared to the PBS control. (g) Comparative GSE analysis between PDX-1 and PDX-2 treated with 7SL1-like RNA-expressing immune cells and mRNA-LNP.

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