Fig. 4 | Scientific Reports

Fig. 4

From: Identification of potential biomarkers associated with mitochondrial oxidative stress in idiopathic pulmonary arterial hypertension via bioinformatic and experimental analysis

Fig. 4

Identification of hub genes based on machine learning. (A–B) Coefficient paths at different λ values (A) and ten-fold cross-validation curve (B) in the LASSO regression. (C–D) The error rate (C) and accuracy rate (D) of the number of variables in the SVM-RFE method. (E) The performance of the RF model varies with the number of trees. (F) Venn diagram illustrating the hub genes selected by the three algorithms. (G) Relative expression of two hub genes (COX6B1 and HMGCL) between IPAH and control groups. ∗∗∗P < 0.001 versus control group.

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