Table 1 Demographic and clinical data of subjects under study.

Gender (M/F)

192/282

238/190

197/162

178/125

Age (years)

74.95\(\:\pm\:\)04.67

73.01 ± 06.65

74.06 ± 06.91

74.12 ± 06.70

Education (y)

17.52 ± 01.69

15.22 ± 01.80

15.89 ± 02.18

14.92 ± 01.98

FAQ

00.11 ± 00.53

01.90 ± 032.95

05.88 ± 04.84

12.82 ± 06.85

MMSE

22.98 ± 01.24

23.33 ± 01.93

25.92 ± 02.27

22.84 ± 02.74

MoCA

26.07 ± 02.35

22.94 ± 01.95

22.87 ± 01.94

19.08 ± 02.98

FDG

05.84 ± 01.03

05.98 ± 01.99

06.57 ± 00.80

06.02 ± 00.92

APOe4

01.79 ± 01.58

01.83 ± 01.96

01.64 ± 01.31

01.25 ± 01.01

p-TAU (pg/mL)

21.68 ± 06.59

23.10 ± 11.06

28.10 ± 11.06

38.10 ± 12.52

TAU

239.04 ± 78.02

272.53 ± 115

328.02 ± 120

370.02 ± 122.02

ADAS 11

04.93 ± 01.99

08.52 ± 4.01

11.52 ± 04.01

18.04 ± 05.29

ADAS13

09.01 ± 03.59

13.59 ± 04.24

21.05 ± 05.46

31.10 ± 08.01

RAVLT learning

05.65 ± 01.99

03.97 ± 01.85

03.08 ± 01.98

02.23 ± 02.05

RAVLT forget

04.02 ± 01.85

05.14 ± 01.73

04.97 ± 01.59

05.00 ± 02.03

RAVLT % forget

34.95 ± 25.03

52.56 ± 32.56

74.95 ± 25.80

59.34 ± 19.06

CDR

01.001 ± 0.30

02.00 ± 01.02

01.95 ± 01.09

04.24 ± 01.95

AV45

02.01 ± 01.02

02.08 ± 01.03

02.21 ± 01.20

02.54 ± 01.08

HCI

07.92 ± 02.08

12.01 ± 03.92

15.03 ± 05.05

21.02 ± 06.38

Hippo. volume

06.82 ± 01.54

05.18 ± 2.11

05.09 ± 02.03

04.54 ± 02.05

Ventricles

08.21 ± 1.26

10.30 ± 01.65

10.30 ± 01.65

10.30 ± 01.65

Whole brain volume

11.85 ± 01.34

11.85 ± 01.34

11.85 ± 01.34

11.85 ± 01.34

Entorhinal cortical volume

04.01 ± 01.35

04.01 ± 01.35

04.01 ± 01.35

04.01 ± 01.35

Fusiform cortical volume

08.78 ± 01.49

07.67 ± 01.52

07.04 ± 01.38

06.41 ± 01.31

Middle temporal cortical volume

08.12 ± 01.33

08.12 ± 01.33

08.12 ± 01.33

08.12 ± 01.33

Intracranial volume

1496.02 ± 145.7

1496.02 ± 145.7

1496.02 ± 145.7

1496.02 ± 145.7