Fig. 1 | Scientific Reports

Fig. 1

From: The translation factor eIF4E is a key mediator of doxorubicin resistance: insights from a triple-negative breast cancer model

Fig. 1

Generation of chemoresistance phenotype using doxorubicin IC25 (0.3 µM). (A) General scheme of the protocol for chemoresistance generation. (B) Dose-response curve under treatment with dox (0–6.4 µM) in MDAN and MDAR variant cells at 48 h treatment. (C) IC50 values for the MDAN and MDAR cell variants, assays corresponding to three biological replicates (x ± S.D). The mean values are presented (n = 3, mean ± SD); data were statistically analyzed using one-way ANOVA and Newman–Keuls’s multiple comparison test, * p < 0.05. (1) FBS: Fetal bovine serum; (2) MDAN: MDA native 3: MDAR: MDA resistant variant.

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