Table 2 The primary Pharmacokinetic parameters of IP DTX injection (n = 4).
From: Influences of formulations and administration routes on docetaxel tissue distribution in mice
Parameter | Plasma | Brain | Heart | Kidneys | Liver | Lung | Lymph Node | Small intestine | Spleen | Stomach |
|---|---|---|---|---|---|---|---|---|---|---|
Cmax (ng/mL) | 1335 ± 963 | 468 ± 218 | 1648 ± 294 | 5907 ± 1243 | 3821 ± 2608 | 2928 ± 680 | 13,185 ± 4394 | 7790 ± 3385 | 7596 ± 1071 | 5284 ± 1260 |
Tmax (h) | 0.500 ± 0.00 | 0.750 ± 0.289 | 1.88 ± 1.55 | 1.25 ± 0.866 | 0.875 ± 0.750 | 1.00 ± 0.707 | 0.500 ± 0.00 | 0.875 ± 0.750 | 1.00 ± 0.707 | 1.00 ± 0.707 |
AUClast (h ng/mL) | 1573 ± 499 | 769 ± 82.1 | 7059 ± 409 | 23,436 ± 1471 | 7165 ± 5035 | 9050 ± 1070 | 22,722 ± 6954 | 16,226 ± 1822 | 26,431 ± 3275 | 17,391 ± 10,377 |
AUCinf (h·ng/mL) | 1736 ± 547 | 999 ± 216 | 16,585 ± 10,223 | 29,904 ± 3660 | 7880 ± 4682 | 11,978 ± 671 | 27,186 ± 4546 | 17,586 ± 2488 | 32,651 ± 3958 | 22,381 ± 12,402 |
t1/2 (h) | 1.90 ± 0.584 | 1.78 ± 0.974 | 8.13 ± 6.94 | 3.00 ± 0.718 | 2.06 ± 1.41 | 2.88 ± 0.656 | 3.09 ± 2.40 | 1.78 ± 0.478 | 2.75 ± 0.738 | 2.65 ± 1.24 |
Vd/F (mL/kg) | 8418 ± 2414 | / | / | / | / | / | / | / | / | / |
CL/F (mL/h/kg) | 3174 ± 874 | / | / | / | / | / | / | / | / | |
T/P ratio | / | 0.489 | 4.49 | 14.9 | 4.55 | 5.75 | 14.4 | 10.3 | 16.8 | 11.1 |
F(%) | 100% | / | / | / | / | / | / | / | / | / |
