Fig. 4

Effect of Igf1r haploinsufficiency on metabolic-related parameters in male and female Tg344-AD rats. We crossed igf1r Hets with TgF344-AD rats to generate four experimental groups, respectively. (A,C) In, igf1r Hets, there was a reduction in body weight for both males (WT n = 13; IGF-1R Het n = 11; AD n = 11; Het-AD n = 10) and females (WT n = 10; igf1r Het n = 11; AD n = 12; Het-AD n = 14), relative to non-AD controls. (B,D) As expected, IGF-1R levels in cortex were reduced in both control and TgF344-AD Igf1r Het animals of both sexes (p < 0.001). (E,F) Neither plasma IGF-1 or Insulin levels were significantly altered in male animals. (E,F) In Females, IGF-1 (G; p < 0.001) and insulin concentrations (H; p = 0.0248) were significantly elevated in female Hets, regardless of AD genotype status. Body weight was assessed by Repeated Measures ANOVA while other assessments were performed via two-way ANOVA followed by posthoc tests with Tukey adjustment.