Fig. 3 | Scientific Reports

Fig. 3

From: PD-1/PD-L1 pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats

Fig. 3

BMS-1 exacerbates incision pain by up-regulating neuroinflammation. (A) Experimental flow chart. (B) BMS-1 induced further lower MWT. n = 12. (C) BMS-1 induced further lower TWL. n = 8. (D) The WB test results of PD-1. (E) The statistical result of PD-1expression. n = 3. (F) The statistical result of TNF-α expression. n = 6. (G) The statistical result of IL-1β expression. n = 6. (H) The statistical result of IL-6 expression. n = 6. *P < 0.05, **P < 0.01, ***P < 0.001. Two-way of ANOVA tests and Sidak’s multiple comparisons test was used for statistical behavioral results and unpaired t tests were used for the WB and Elisa.

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