Table 4 Summary of the topmost significantly associated DMRs for each PLR amplitude phenotype.

From: Epigenome-wide analysis identifies DNA methylation signatures associated with the infant pupillary light reflex, a candidate intermediate phenotype for autism

Amplitude phenotype (months)

Genomic locations (hg19)

N probes

Probes

Illumina gene annotation

Effect size (β)1

Bonf.-adjust p-value

9

chr13:103452556–103,453,215

4

cg06518779; cg21251000; cg15186648; cg15193473

BIVM; KDELC1

0.04

2.13 × 10− 4

14

chr11:111249659–111,250,201

5

cg19126910; cg17390301; cg24049888; cg18316498; cg11362935

POU2AF1

−0.03

2.22 × 10− 2

24

chr5:77253833–77,253,990

3

cg25051331; cg09048251; cg07595776

 

−0.08

8.23 × 10− 4

9 to 14

chr10:102295134–102,295,549

5

cg07690778; cg26303175; cg07080220; cg08314679; cg07510080

HIF1AN

0.07

2.67 × 10− 3

14 to 24

chr15:89786761–89,787,223

4

cg22813622; cg01741397; cg15769724; cg06870609

FANCI

−0.04

1.22 × 10− 3

  1. Bonf.-adjust Bonferroni-adjusted. 1A negative effect size (-β) indicates hypermethylation associated with smaller constriction amplitude (for cross-sectional measurements) or constriction becoming larger over time (for change scores).
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