Table 5 Summary of the number of significantly enriched GO terms and the most significant term for each PLR phenotype.

From: Epigenome-wide analysis identifies DNA methylation signatures associated with the infant pupillary light reflex, a candidate intermediate phenotype for autism

Phenotype

(month)

N. sig. enriched GO terms

Most significantly enriched GO term

Description

(GO number)

Fold Enrichment

FDR p-value

PLR latency

 9

12

Homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)

4.2

3.17 × 10− 7

 14

34

Negative regulation of developmental process (GO:0051093)

1.84

6.95 × 10− 3

 24

0

-

-

-

 9 to 14

16

Homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)

6.62

8.27 × 10− 22

 14 to 24

16

Regulation of cellular component organization (GO:0051128)

1.5

5.00 × 10− 3

PLR amplitude

 9

0

-

-

-

 14

73

Regulation of glucuronosyltransferase activity (GO:1904223)

24.41

3.86 × 10− 8

 24

0

-

-

-

 9 to 14

22

System development (GO:0048731)

1.41

1.30 × 10− 3

 14 to 24

0

-

-

-

  1. sig. significant after False discovery rate (FDR) adjustment.