Fig. 6 | Scientific Reports

Fig. 6

From: Ubiquitin-specific protease 14 inhibition promotes mitophagy and attenuates neural apoptosis after spinal cord injury

Fig. 6

3-MA inhibits the protective effects of USP14 inhibition against mitochondrial dysfunction and apoptosis. (A,B) Western blotting and semi-quantitative analysis of apoptosis-related proteins (Bax/Bcl-2, Cleaved-caspase-3/Caspase-3, Cleaved-caspase-9/Caspase-9), autophagy-related proteins (LC3B II/I, P62), and mitochondrial-related proteins (ATPB, TOM20) following OGD and 3-MA treatment (mean ± SD, n = 3). Statistical analysis was performed using one-way ANOVA to determine p-values for the mean ± standard deviation from three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

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